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KMID : 0353320140380010001
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Oral Biology Research
2014 Volume.38 No. 1 p.1 ~ p.8
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Bisphosphonate-related osteonecrosis of the jaws: A literature review
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Oh Ji-Su
Kim Su-Gwan
You Jae-Seek
Kim Ji-Won
Kim Eun-Sik
Lim Kyung-Seop
Kim Cheol-Man
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Abstract
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The aim of the present study was to review bisphosphonate osteonecrosis of the jaws (BRONJ). Bisphosphonate, pathophysiology, risk factors, staging, clinical manifestation, treatments, and prevention of BRONJ were investigated through a literature search. Bisphosphonates are a group of drugs that treat diseases related to bone resorption such as Paget`s disease, osteoporosis, and osseous metastases. BRONJ is defined as exposure and necrosis of bone in the oral cavity for at least 8 weeks in patients receiving bisphosphonate and with no history of radiotherapy of the jaws. Many articles have reported risk factors associated with BRONJ such as systemic diseases, oral infection, poor oral hygiene, and intraoral trauma. The objectives of BRONJ treatment are to minimize necrosis and relieve symptoms. Many treatments are suggested from conservative treatment to radical intervention, but this remains controversial. BRONJ remains a difficult condition to treat although many studies are being carried out.
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KEYWORD
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Jaw, Necrosis, Oral surgery, Osteomyelitis
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